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Title
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The growth hormone/insulin-like growth factor axis - What is its role in the atherosclerotic process? = L’endocrinologie cardiovasculaire : un rôle pour l'axe hormone de croissance/insulin-like growth factor dans le processus athéroscléreux?
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Author
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Abstract
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| Growth hormone and atherosclerosis Adult-onset growth hormone (GH) deficiency is associated with an increase in cardiovascular morbidity and mortality. Mechanisms Other than classical risk factors, such as dyslipidemia, a direct interaction between the activity of the GH/IGF-1 axis and the endothelium also plays a part. It is possible that the modulating effect of IGF-1 on nitric oxide (NO) synthesis is also important, together with the anabolic effect on the myocardiocytes. Substitution of recombinant GH induces rapid reduction in the atherosclerotic plaques, suggesting a direct effect of the GH/IGF axis on the atherosclerotic process. In addition to the acquired GH deficiency, as in non-substituted patients following hypophysectomy, attention has recently been focused on the relative GH deficiency as is seen in obesity and in the course of ageing. Perspectives for cardiovascular endocrinology Therapeutic intervention in the GH/IGF axis might influence the atherosclerotic process. Study of the GH/IGF axis activity and of its correlation with atherosclerosis opens new perspectives in the understanding of the role of this axis in cardiovascular diseases. |
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Language
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French
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Source (journal)
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La presse médicale (1983). - Paris, 1983, currens
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Publication
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Paris
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Masson
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2003
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ISSN
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0755-4982
[print]
2213-0276
[online]
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Volume/pages
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32
:26
(2003)
, p. 1238-1243
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ISI
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000184758400013
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Pubmed ID
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14506468
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