Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada : results of the Dyslipidaemia International Study

Leiter, L.A.; Lundman, P.; da Silva, P.M.; Drexel, H.; Jünger, C.; Gitt, A.K.; Twickler, Th. B.; et al.

doi:10.1111/J.1464-5491.2011.03360.X

Title

Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada : results of the Dyslipidaemia International Study

Author

Leiter, L.A.

Lundman, P.

da Silva, P.M.

Drexel, H.

Jünger, C.

Gitt, A.K.

Twickler, Th. B.

et al.

Institution/Organisation

DYSIS investigators

Abstract

Aim: To assess the prevalence of persistent lipid abnormalities in statin-treated patients with diabetes with and without the metabolic syndrome. Methods: This was a cross-sectional study of 22,063 statin-treated outpatients consecutively recruited by clinicians in Canada and 11 European countries. Patient cardiovascular risk factors, risk level, lipid measurements and lipid-modifying medication regimens were recorded. Results: Of the 20,129 subjects who had documented diabetes and/or metabolic syndrome status, 41% had diabetes (of whom 86.8% also had the metabolic syndrome). Of those with diabetes, 48.1% were not at total cholesterol target compared with 58% of those without diabetes. Amongst those with diabetes, 41.6 and 41.3% of those with and without the metabolic syndrome, respectively, were not at their LDL cholesterol goal relative to 54.2% of those with metabolic syndrome and without diabetes, and 52% of those with neither condition. Twenty per cent of people with diabetes but without the metabolic syndrome were not at the optimal HDL cholesterol level compared with 9% of those with neither condition. Of people with diabetes and the metabolic syndrome, 49.9% were not at optimal triglyceride level relative to 13.5% of people with neither diabetes nor the metabolic syndrome. Simvastatin was the most commonly prescribed statin (>45%) and the most common statin potency was 20-40 mg/day (simvastatin equivalent). Approximately 14% of patients were taking ezetimibe alone or in combination with a statin. Conclusions: Despite evidence supporting the benefits of lipid modification and international guideline recommendations, statin-treated patients with diabetes had a high prevalence of persistent lipid abnormalities. There is frequently room to optimize therapy through statin dose up-titration and/or addition of other lipid-modifying therapies.

Language

English

Source (journal)

Diabetic medicine / Diabetes UK. - [S.l.], 1984, currens

Publication

[S.l.] : Wiley-Blackwell , 2011

ISSN

1464-5491

DOI

10.1111/J.1464-5491.2011.03360.X

Volume/pages

28 :11 (2011) , p. 1343-1351