The protective effects of the autophagic and lysosomal machinery in vascular and valvular calcification : a systematic review

Neutel, Cédric H.G.; Hendrickx, Jhana O.; Martinet, Wim; De Meyer, Guido R.Y.; Guns, Pieter-Jan

doi:10.3390/IJMS21238933

Title

The protective effects of the autophagic and lysosomal machinery in vascular and valvular calcification : a systematic review

Author

Neutel, Cédric H.G.

Hendrickx, Jhana O.

Martinet, Wim

De Meyer, Guido R.Y.

Guns, Pieter-Jan

Abstract

Background: Autophagy is a highly conserved catabolic homeostatic process, crucial for cell survival. It has been shown that autophagy can modulate different cardiovascular pathologies, including vascular calcification (VCN). Objective: To assess how modulation of autophagy, either through induction or inhibition, affects vascular and valvular calcification and to determine the therapeutic applicability of inducing autophagy. Data sources: A systematic review of English language articles using MEDLINE/PubMed, Web of Science (WoS) and the Cochrane library. The search terms included autophagy, autolysosome, mitophagy, endoplasmic reticulum (ER)-phagy, lysosomal, calcification and calcinosis. Study characteristics: Thirty-seven articles were selected based on pre-defined eligibility criteria. Thirty-three studies (89%) studied vascular smooth muscle cell (VSMC) calcification of which 27 (82%) studies investigated autophagy and six (18%) studies lysosomal function in VCN. Four studies (11%) studied aortic valve calcification (AVCN). Thirty-four studies were published in the time period 2015–2020 (92%). Conclusion: There is compelling evidence that both autophagy and lysosomal function are critical regulators of VCN, which opens new perspectives for treatment strategies. However, there are still challenges to overcome, such as the development of more selective pharmacological agents and standardization of methods to measure autophagic flux.

Language

English

Source (journal)

International journal of molecular sciences

Publication

2020

ISSN

1422-0067

1661-6596

DOI

10.3390/IJMS21238933

Volume/pages

21 :23 (2020) , 27 p.

Article Reference

8933

ISI

000597595900001

Pubmed ID

33255685

Medium

E-only publicatie

Full text (Publisher's DOI)

https://doi.org/10.3390/IJMS21238933

Full text (open access)

Licensed under a CC BY Attribution license

Faculty/Department				Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences

Research group				Physiopharmacology (PHYSPHAR)
Project info				Infla-Med: Fundamental and translational research into targets for the treatment of inflammatory diseases. From hit to lead: inducing basal autophagy for treating cardiovascular disease. Pharmacological modulation of autophagy in vascular disease. Investigating the role of autophagy in arterial calcification and arterial stiffness. From hit to lead: inducing basal autophagy for treating cardiovascular diseases. Arterial stiffening as a common pathophysiological mechanism in cardiac and kidney failure and brain degeneration.
Publication type				A1 Journal article

Subject				Chemistry Biology Human medicine

Affiliation				Publications with a UAntwerp address

Web of Science

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Identifier

Creation

30.11.2020

Last edited

13.11.2024

To cite this reference

https://hdl.handle.net/10067/1734690151162165141