|
Title
|
|
|
|
Case report : dynamics of acquired fluoroquinolone resistance under standardized short-course treatment of multidrug-resistant tuberculosis
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Acquired resistance was identified at the ninth month of treatment, 3 months after stopping kanamycin in a strain initially susceptible only to FQs, kanamycin, and clofazimine. Fluoroquinolone resistance was detected in the same month by deep sequencing as routinely used second-line line probe assay and phenotypic drug susceptibility testing. High-dose FQ, preferably gatifloxacin, should be used to maximize effectiveness. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
The American journal of tropical medicine and hygiene. - Baltimore, Md
| |
|
Publication
|
|
|
|
Baltimore, Md
:
2020
| |
|
ISSN
|
|
|
|
0002-9637
| |
|
DOI
|
|
|
|
10.4269/AJTMH.20-0201
| |
|
Volume/pages
|
|
|
|
103
:4
(2020)
, p. 1443-1446
| |
|
ISI
|
|
|
|
000580818500025
| |
|
Pubmed ID
|
|
|
|
32618257
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|