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Title
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On the anti-cancer effect of cold atmospheric plasma and the possible role of catalase-dependent apoptotic pathways
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Author
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Abstract
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| Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in particular has been postulated in great detail and consists of a very complex network of reactions that are claimed to account for the anti-cancer effect of CAP. Here, the key concept is a reactivation of two specific apoptotic cell signaling pathways through catalase inactivation caused by CAP. Thus, it is postulated that the anti-cancer effect of CAP is due to its ability to inactivate catalase, either directly or indirectly. A theoretical investigation of the proposed theory, especially the role of catalase inactivation, can contribute to the understanding of the underlying cause of the anti-cancer effect of CAP. In the present study, we develop a mathematical model to analyze the proposed catalase-dependent anti-cancer effect of CAP. Our results show that a catalase-dependent reactivation of the two apoptotic pathways of interest is unlikely to contribute to the observed anti-cancer effect of CAP. Thus, we believe that other theories of the underlying cause should be considered and evaluated to gain knowledge about the principles of CAP-induced cancer cell death. |
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Language
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English
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Source (journal)
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Cells
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Publication
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2020
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DOI
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10.3390/CELLS9102330
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Volume/pages
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9
:10
(2020)
, 33 p.
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Article Reference
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2330
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ISI
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000584186700001
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Pubmed ID
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33096638
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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