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Title
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Neurodevelopmental outcomes of very preterm and very-low-birthweight infants in a population-based clinical cohort with a definite perinatal treatment policy
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Author
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Abstract
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| Background: With constant changes in neonatal care practices, recent information is valuable for healthcare providers and for parental counselling. The aim of the study was to describe the neuro-developmental outcome in a cohort of very preterm (VPT)/very-low-birthweight (VLBW) infants at 2 years corrected age (CA). Material and methods: This is a population-based cohort study of all infants born with a GA <31 weeks and/or BW <1500 g between 2014 and 2016 admitted to the Flemish (Belgium) neonatal intensive care units. Infants had routine clinical follow-up around 2 years CA. The diagnosis of cerebral palsy (CP), visual and hearing impairments were recorded. Motor, cognitive and language outcomes were assessed using the Bayley-III. Neurodevelopmental impairment (NDI) was classified as mild (<1 standard deviation [SD]) or moderate-severe (<2SD) based on the defined categories of motor, cognitive, hearing, and vision impairments. Results: Of the 1941 admissions, 92% survived to discharge and follow-up data were available for 1089 infants (61.1%). Overall, 19.3%, 18.9% and 41.8% of infants had a motor, cognitive and language delay, respectively. CP was diagnosed in 4.3% of the infants. Mild and moderate-to-severe NDI was observed in 25.2% and 10.9% of the infants, respectively. The number of infants with a normal outcome increased from nearly 40% in the category of GA<26 weeks to 70% for infants in the category of 30-31 weeks GA. Conclusion: At 2 years CA, 64% were free from NDI and 90% were free from moderate-to-severe NDI. However, a lower GA and BW are associated with higher rates of adverse neurodevelopmental outcomes at 2 years CA. (c) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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European journal of paediatric neurology. - London
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Publication
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London
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2020
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ISSN
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1090-3798
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DOI
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10.1016/J.EJPN.2020.06.007
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Volume/pages
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28
(2020)
, p. 133-141
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ISI
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000579769100020
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Pubmed ID
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32788055
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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