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Title
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Effect of plasma-induced oxidative stress on the glycolysis pathway of Escherichia coli
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Author
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Abstract
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| Antibiotic resistance is one of the world's most urgent public health problems. Due to its antibacterial properties, cold atmospheric plasma (CAP) may serve as an alternative method to antibiotics. It is claimed that oxidative stress caused by CAP is the main reason of bacteria inactivation. In this work, we computationally investigated the effect of plasma-induced oxidation on various glycolysis metabolites, by monitoring the production of the biomass. We observed that in addition to the significant reduction in biomass production, the rate of some reactions has increased. These reactions produce anti-oxidant products, showing the bacterial defense mechanism to escape the oxidative damage. Nevertheless, the simulations show that the plasma-induced oxidation effect is much stronger than the defense mechanism, causing killing of the bacteria. |
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Language
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English
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Source (journal)
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Computers in biology and medicine. - Oxford
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Publication
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Oxford
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2020
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ISSN
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0010-4825
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DOI
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10.1016/J.COMPBIOMED.2020.104064
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Volume/pages
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127
(2020)
, 12 p.
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Article Reference
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104064
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ISI
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000603362700001
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Pubmed ID
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33171288
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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