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Title
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Microglia require CD4 T cells to complete the fetal-to-adult transition
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Author
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Abstract
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| The brain is a site of relative immune privilege. Although CD4 T cells have been reported in the central nervous system, their presence in the healthy brain remains controversial, and their function remains largely unknown. We used a combination of imaging, single cell, and surgical approaches to identify a CD69(+) CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells. The brain-resident population was derived through in situ differentiation from activated circulatory cells and was shaped by self-antigen and the peripheral microbiome. Single-cell sequencing revealed that in the absence of murine CD4 T cells, resident microglia remained suspended between the fetal and adult states. This maturation defect resulted in excess immature neuronal synapses and behavioral abnormalities. These results illuminate a role for CD4 T cells in brain development and a potential interconnected dynamic between the evolution of the immunological and neurological systems. |
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Language
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English
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Source (journal)
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Cell. - Cambridge, Mass.
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Publication
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Cambridge, Mass.
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2020
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ISSN
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0092-8674
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DOI
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10.1016/J.CELL.2020.06.026
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Volume/pages
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182
:3
(2020)
, p. 625-640.e24
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ISI
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000558649000010
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Pubmed ID
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32702313
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Full text (Publisher's DOI)
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Full text (open access)
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