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Title
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The gimbaled-head radiotherapy system : rise and downfall of a dedicated system for dynamic tumor tracking with real-time monitoring and dynamic WaveArc
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Author
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Abstract
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| A gimbaled-head radiotherapy device was developed by industry-academic collaborations, with a concept of robust structures whilst maintaining high flexibilities, and its clinical application started in 2008. The unique structures with multi-image guidance functions initiated 2 new treatment modalities. One is dynamic tumor tracking radiotherapy with real time monitoring (DTTRM), which enables 4-D radiotherapy without prolongation of radiotherapy treatment time. This treatment has become clinically feasible for stereotactic body radiotherapy (SBRT) of lung cancers and liver tumors, and intensity-modulated radiotherapy (IMRT) for pancreatic cancers. The second one is Dynamic WaveArc therapy (DWA), the non-coplanar versatility of the SBRT system by combining the gantry-ring synchronized rotation with dynamic multileaf collimator optimization. DWA opens the possibility to create patient-individualized treatment plans, allowing additional flexibility in organ at risk sparing while preserving dosimetric robust delivery. The clinical usefulness of the DWA has been preliminary shown for those tumors in the prostate, breast and skull base. Prospective clinical trials are under way with a support of the national funding of Japan for DTTRM and DWA, respectively. Marketing of the system was terminated in 2016 due to a commercial decision. However, lessons can be learned from the development process of this device that might be useful for those who have interests in new technologies and clinical applications in radiation oncology. This review article aims to summarize the developments and achievements of a gimbaled-head radiotherapy device with a focus on DTTRM and DWA. (C) 2020 The Author(s). Published by Elsevier B.V. |
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Language
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English
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Source (journal)
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Radiotherapy and oncology. - Amsterdam
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Publication
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Amsterdam
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2020
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ISSN
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0167-8140
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DOI
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10.1016/J.RADONC.2020.07.002
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Volume/pages
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153
(2020)
, p. 311-318
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ISI
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000600731700039
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Pubmed ID
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32659250
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Full text (Publisher's DOI)
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Full text (open access)
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