Wearable potentiometric ion patch for on-body electrolyte monitoring in sweat : toward a validation strategy to ensure physiological relevance

Parrilla, Marc; Ortiz-Gomez, Inmaculada; Cánovas, Rocio; Salinas-Castillo, Alfonso; Cuartero, Maria; Crespo, Gaston A.

doi:10.1021/ACS.ANALCHEM.9B02126

Title

Wearable potentiometric ion patch for on-body electrolyte monitoring in sweat : toward a validation strategy to ensure physiological relevance

Author

Parrilla, Marc

Ortiz-Gomez, Inmaculada

Cánovas, Rocio

Salinas-Castillo, Alfonso

Cuartero, Maria

Crespo, Gaston A.

Abstract

Herein, the reproducibility and a double validation of on-body measurements provided by new wearable potentiometric ion sensors (WPISs) is presented. Sweat collected during sport practice was first analyzed using the developed device, the pH-meter, and ion chromatography (IC) prior to onbody measurements (off-site validation). Subsequently, the accuracy of onbody measurements accomplished by the WPISs was evaluated by comparison with pH-meter readings and IC after collecting sweat (every 10-12.5 min) during sport practice. The developed device contains sensors for pH, Cl-, K+, and Na+ that are embedded in a flexible sampling cell for sweat analysis. The electrode array was fabricated employing MWCNTs (as an ion-to-electron transducer) and stretchable materials that have been exhaustively characterized in terms of analytical performance, presenting Nernstian slopes within the expected physiological range of each ion analyte (Cl-, 10-100 mM; 10-10 mM; and Na+, 10- 100 mM and pH, 4.5-7.5), drift suitable for midterm exercise practice (0.3 +/- 0.2 mV h(-1)), fast response time, adequate selectivity for sweat measurements, and excellent reversibility. Besides that, the designed sampling cell avoids any sweat contamination and evaporation issues while supplying a passive sweat flow encompassing specifically the individual's perspiration. The interpretation of ion concentration profiles may permit the identification of personal dynamic patterns in sweat composition while practicing sport.

Language

English

Source (journal)

Analytical chemistry. - Washington, D.C., 1948, currens

Publication

Washington, D.C. : 2019

ISSN

0003-2700 [print]

5206-882X [online]

DOI

10.1021/ACS.ANALCHEM.9B02126

Volume/pages