Publication
Title
The neonatal and juvenile pig in pediatric drug discovery and development
Author
Abstract
Pharmacotherapy in pediatric patients is challenging in view of the maturation of organ systems and processes that affect pharmacokinetics and pharmacodynamics. Especially for the youngest age groups and for pediatric-only indications, neonatal and juvenile animal models can be useful to assess drug safety and to better understand the mechanisms of diseases or conditions. In this respect, the use of neonatal and juvenile pigs in the field of pediatric drug discovery and development is promising, although still limited at this point. This review summarizes the comparative postnatal development of pigs and humans and discusses the advantages of the juvenile pig in view of developmental pharmacology, pediatric diseases, drug discovery and drug safety testing. Furthermore, limitations and unexplored aspects of this large animal model are covered. At this point in time, the potential of the neonatal and juvenile pig as nonclinical safety models for pediatric drug development is underexplored.
Language
English
Source (journal)
Pharmaceutics
Publication
2020
ISSN
1999-4923
DOI
10.3390/PHARMACEUTICS13010044
Volume/pages
13 :1 (2021) , 36 p.
Article Reference
44
ISI
000610720100001
Pubmed ID
33396805
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Infradev - European Paediatric Translational Research Infrastructure (ID-EPTRI).
Ontogeny of drug transporters and metabolizing enzymes in the minipig: a genomic approach
Gene expression profiling in the gastrointestinal system of normal and intra-uterine growth restricted pigs: a strategy to understand the molecular machinery underlying intestinal changes in preterm babies.
Qualification of the juvenile minipig for pediatric safety testing of single stranded oligonucleotides (SSOs).
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 16.02.2021
Last edited 28.01.2024
To cite this reference