Publication
Title
Cancer risk in immune-mediated inflammatory diseases (IMID)
Author
Abstract
Inflammation and cancer have a profound yet ambiguous relationship. Inflammation - especially chronic inflammation - has protumorigenic effects, but inflammatory cells also mediate an immune response against the tumor and immunosuppression is known to increase the risk for certain tumors. This article reviews current literature on the role of inflammation in cancer and the cancer risk in immune-mediated inflammatory diseases (IMIDs). We discuss the effect on cancer risk of different drug classes used in the treatment of IMIDs treatment, including biologicals such as tumor necrosis factor (TNF) inhibitors. Overall cancer incidence and mortality risk are similar to the general population in inflammatory bowel disease (IBD), and slightly increased for rheumatoid arthritis and psoriasis, with risk profiles differing for different tumor types. Increased risk for non-melanoma skin cancer is associated with thiopurine treatment in IBD, with the combination of anti-TNF and methotrexate in rheumatoid arthritis and with PUVA, cyclosporine and anti-TNF treatment in psoriasis. Data on the safety of using biologic or immunosuppressant therapy in IMID patients with a history of cancer are scarce. This review provides clinicians with a solid background to help them in making decisions about treatment of immune-mediated diseases in patients with a tumor history.
Language
English
Source (journal)
Molecular cancer. - London
Publication
London : 2013
ISSN
1476-4598
DOI
10.1186/1476-4598-12-98
Volume/pages
12 :1 (2013) , p. 1-12
Article Reference
98
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
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Publication type
Subject
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Creation 04.03.2021
Last edited 04.03.2024
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