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Title
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Cytoreductive surgery and Hyperthermic intra-operative peritoneal chemotherapy with Cisplatin for gastric peritoneal Carcinomatosis Monocentric phase-2 nonrandomized prospective clinical trial
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Author
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Abstract
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| Background: Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking. Methods: Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%). Median PCI score was 8 (range 1-20), number of regions involved was 6 (range 1-11). The impact of 16 prognostic factors on survival was evaluated using univariable and multivariable Cox regression models. Followup was complete in all patients, and closed 2 years after patient inclusion. Results: All patients had complete cytoreduction (CCR-0) and histopathological R0 resection. PCI Conclusions: CRS + HIPC with cisplatin to treat gastric PC, providing complete cytoreduction and R0 resection, should be restricted to patients with PCI of 12 or less. Patients having PC on any small bowel region with 4 or more non-small bowel regions should be refused for CRS + HIPC. |
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Language
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English
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Source (journal)
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BMC cancer. - London
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Publication
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London
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2017
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ISSN
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1471-2407
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DOI
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10.1186/S12885-017-3730-6
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Volume/pages
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17
:1
(2017)
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Article Reference
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771
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ISI
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000415578100001
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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