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Title
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Endogenous antioxidants in the prognosis and treatment of lung cancer
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Author
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Abstract
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| Cancer cells are characterized by a higher oxidative stress state and are therefore strongly dependent on antioxidant defense systems to maintain their redox homeostasis. Overexpression of endogenous antioxidants is a common feature in lung cancer cells and is often associated with a worse prognosis. This provides a promising therapeutic window for inhibitors of endogenous antioxidants to selectively target cancer cells. In this chapter, we discuss the prognostic value of the transcriptional regulator Nrf2 and the glutathione and thioredoxin antioxidant systems in non-small cell lung cancer. In addition, we highlight therapeutic strategies that impact these endogenous antioxidants either as monotherapy or in combination therapies to overcome resistance to conventional therapies. |
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Language
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English
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Source (book)
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Cancer : oxidative stress and dietary antioxidants / Preedy, V.R. [edit.]; Patel, V.B. [edit.]
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Publication
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Academic Press
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2021
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ISBN
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978-0-12-819547-5
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DOI
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10.1016/B978-0-12-819547-5.00004-3
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Volume/pages
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p. 39-48
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Edition
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Second Edition
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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