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Title
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Radiation-induced cardiovascular disease : an overlooked role for DNA methylation?
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Author
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Abstract
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| Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin's lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis. [GRAPHICS] . |
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Language
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English
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Source (journal)
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Epigenetics : official journal of the DNA methylation society. - Georgetown, Tex., 2006, currens
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Publication
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Philadelphia
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Taylor & francis inc
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2022
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ISSN
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1559-2294
[print]
1559-2308
[online]
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DOI
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10.1080/15592294.2021.1873628
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Volume/pages
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17
:1
(2022)
, p. 59-80
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ISI
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000613355600001
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Pubmed ID
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33522387
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Full text (Publisher's DOI)
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Full text (open access)
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