|
Title
|
|
|
|
The p48 flow diverter : first clinical results in 25 aneurysms in three centers
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Background The novel low-profile p48 flow diverter has been designed to treat aneurysms on small vessels of 1.75-3mm. We report our first clinical experiences. Methods Between March 2018-January 2020, 22 patients with 25 aneurysms were treated with the p48 in 3 centers. One patient had 3 aneurysms covered by one p48 and one patient had 2 aneurysms. There were 5 men, 17 women, with a mean age of 55 years (median 59, range 29-73 years). Results In 25 aneurysms, 24 p48 flow diverters were placed. In 1 patient additional coils were placed in the aneurysm. Procedural vessel rupture by the micro guidewire occurred in 2 patients and vessel rupture during p48 balloon dilatation occurred in 1 patient. Overall, the permanent morbidity rate was 13.6% (3 of 22, 95%CI 3.9-34.2%) and mortality was 4.5% (1 of 22, 95%CI <0.01-23.5%). Most complications were procedure-related and not device-specific. Of 22 patients with 25 aneurysms treated with p48, 18 patients with 20 aneurysms had angiographic follow-up after 5-18 months. Of 19 aneurysms, 10 were occluded and 7 showed a remnant. Two aneurysms were open after 6 months. Three aneurysms were still not occluded after 12, 14, and 18 months and these 3 were retreated. Retreatment rate was 16% (3 of 19) and the adequate occlusion rate was 90% (17 of 19). Conclusions Treatment of aneurysms in small-caliber vessels with the p48 is feasible and effective but is not without complications. More data is needed to establish indications, safety, and efficacy more accurately. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences. - Milan, 1995, currens
| |
|
Publication
|
|
|
|
Thousand oaks
:
Sage publications inc
,
2021
| |
|
ISSN
|
|
|
|
1591-0199
| |
|
DOI
|
|
|
|
10.1177/1591019920972213
| |
|
Volume/pages
|
|
|
|
27
:3
(2021)
, p. 339-345
| |
|
Article Reference
|
|
|
|
1591019920972213
| |
|
ISI
|
|
|
|
000618417500001
| |
|
Pubmed ID
|
|
|
|
33164617
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|