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Title
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Efficient demethylation of aromatic methyl ethers with HCl in water
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Author
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Abstract
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| A green, efficient and cheap demethylation reaction of aromatic methyl ethers with mineral acid (HCl or H2SO4) as a catalyst in high temperature pressurized water provided the corresponding aromatic alcohols (phenols, catechols, pyrogallols) in high yield. 4-Propylguaiacol was chosen as a model, given the various applications of the 4-propylcatechol reaction product. This demethylation reaction could be easily scaled and biorenewable 4-propylguaiacol from wood and clove oil could also be applied as a feedstock. Greenness of the developed method versus state-of-the-art demethylation reactions was assessed by performing a quantitative and qualitative Green Metrics analysis. Versatility of the method was shown on a variety of aromatic methyl ethers containing (biorenewable) substrates, yielding up to 99% of the corresponding aromatic alcohols, in most cases just requiring simple extraction as work-up. |
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Language
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English
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Source (journal)
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Green chemistry : cutting-edge research for a greener sustainable future / Royal Society of Chemistry [London] - London, 1999, currens
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Publication
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London
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Royal Society of Chemistry
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2021
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ISSN
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1463-9262
[print]
1463-9270
[online]
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DOI
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10.1039/D0GC04268D
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Volume/pages
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23
:5
(2021)
, p. 1995-2009
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ISI
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000628913600011
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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