|
Title
|
|
|
|
The future of blood testing is the immunome
| |
|
Author
|
|
|
|
| |
|
Institution/Organisation
|
|
|
|
Adaptive Immune Receptor Repertoire Community
| |
|
Abstract
|
|
|
|
| It is increasingly clear that an extraordinarily diverse range of clinically important conditions—including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers—leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person’s B cells (antibodies) and T cells. We refer to these as the immunome. Because of its diversity and complexity, the immunome provides singular opportunities for advancing personalized medicine by serving as the substrate for a highly multiplexed, near-universal blood test. Here we discuss some of these opportunities, the current state of immunome-based diagnostics, and highlight some of the challenges involved. We conclude with a call to clinicians, researchers, and others to join efforts with the Adaptive Immune Receptor Repertoire Community (AIRR-C) to realize the diagnostic potential of the immunome. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Frontiers in immunology. - Place of publication unknown
| |
|
Publication
|
|
|
|
Place of publication unknown
:
2021
| |
|
ISSN
|
|
|
|
1664-3224
| |
|
DOI
|
|
|
|
10.3389/FIMMU.2021.626793
| |
|
Volume/pages
|
|
|
|
12
(2021)
, 6 p.
| |
|
Article Reference
|
|
|
|
626793
| |
|
Pubmed ID
|
|
|
|
33790897
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (open access)
|
|
|
|
| |
|