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Title
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Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats
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Author
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Abstract
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| Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was investigated in a hemi-Parkinson rat model, using semiquantitative western blotting. We observed time-dependent changes after a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway with increased expression levels in the deafferented striatum after 3 weeks. Twelve weeks postlesion, expression levels returned to normal. These data suggest, for the first time, an involvement of the cystine/glutamate antiporter in determining the aberrant glutamate neurotransmission in the striatum of a parkinsonian brain. NeuroReport 19:1589--1592 (C) Wolters Kluwer Health | Lippincott Williams & Wilkins. |
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Language
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English
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Source (journal)
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Neuroreport. - Oxford
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Publication
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Oxford
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2008
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ISSN
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0959-4965
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DOI
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10.1097/WNR.0B013E328312181C
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Volume/pages
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19
:16
(2008)
, p. 1589-1592
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ISI
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000260438100007
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Pubmed ID
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18806690
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Full text (Publisher's DOI)
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