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Title
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Molecular imaging of apoptosis : the case of caspase-3 radiotracers
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Author
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Abstract
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| The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved in apoptosis, activated caspase-3 is an attractive target, as it is the most abundant of the executioner caspases. Nuclear imaging is a good candidate, as it combines a high depth of tissue penetration and high sensitivity, features necessary to detect small changes in levels of apoptosis. However, designing a caspase-3 radiotracer comes with challenges, such as selectivity, cell permeability and transient caspase-3 activation. In this review, we discuss the different caspase-3 radiotracers for the imaging of apoptosis together with the challenges of the translation of various apoptosis-imaging strategies in clinical trials. |
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Language
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English
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Source (journal)
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International journal of molecular sciences
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Publication
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Basel
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Mdpi
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2021
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ISSN
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1422-0067
1661-6596
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DOI
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10.3390/IJMS22083948
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Volume/pages
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22
:8
(2021)
, 19 p.
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Article Reference
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3948
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ISI
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000644309200001
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Pubmed ID
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33920463
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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