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Title
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The effects of dietary and lifestyle interventions among pregnant women with overweight or obesity on early childhood outcomes : an individual participant data meta-analysis from randomised trials
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Author
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Abstract
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| Background: The impact of maternal obesity extends beyond birth, being independently associated with an increased risk of child obesity. Current evidence demonstrates that women provided with a dietary intervention during pregnancy improve their dietary quality and have a modest reduction in gestational weight gain. However, the effect of this on longer-term childhood obesity-related outcomes is unknown. Methods: We conducted an individual participant data meta-analysis from RCTs in which women with a singleton, live gestation between 10(+0) and 20(+0) weeks and body mass index (BMI) >= 25 kg/m(2) in early pregnancy were randomised to a diet and/or lifestyle intervention or continued standard antenatal care and in which longer-term maternal and child follow-up at 3-5 years of age had been undertaken. The primary childhood outcome was BMI z-score above the 90th percentile. Secondary childhood outcomes included skinfold thickness measurements and body circumferences, fat-free mass, dietary and physical activity patterns, blood pressure, and neurodevelopment. Results: Seven primary trials where follow-up of participants occurred were identified by a systematic literature search within the International Weight Management in Pregnancy (i-WIP) Collaborative Group collaboration, with six providing individual participant data. No additional studies were identified after a systematic literature search. A total of 2529 children and 2383 women contributed data. Approximately 30% of all child participants had a BMI z-score above the 90th percentile, with no significant difference between the intervention and control groups (aRR 0.97; 95% CI 0.87, 1.08; p=0.610). There were no statistically significant differences identified for any of the secondary outcome measures. Conclusions: In overweight and obese pregnant women, we found no evidence that maternal dietary and/or lifestyle intervention during pregnancy modifies the risk of early childhood obesity. Future research may need to target the pre-conception period in women and early childhood interventions. |
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Language
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English
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Source (journal)
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BMC medicine. - London
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Publication
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London
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2021
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ISSN
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1741-7015
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DOI
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10.1186/S12916-021-01995-6
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Volume/pages
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19
:1
(2021)
, 15 p.
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Article Reference
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128
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ISI
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000656865700001
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Pubmed ID
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34074261
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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