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Title
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Outcome of lung transplantation in non-idiopathic pulmonary fibrosis interstitial lung disease
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Author
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Abstract
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| Lung transplantation remains the only curative treatment option for selected patients with end-stage interstitial lung disease (ILD). Candidate selection is impeded by patient heterogeneity, particularly in the subgroup of non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases. We performed a descriptive analysis of all non-IPF ILD patients who underwent lung transplantation in our center between July 1991 and November 2016 (n = 129) and searched for pre-transplant variables correlating with graft loss and chronic lung allograft dysfunction (CLAD). Our study cohort was characterized by a significantly affected medical condition, an extensive pre-transplant corticosteroid use (73.8%), and a high prevalence of pulmonary hypertension (55.7%). Earlier year of transplantation (P = .004), higher bilirubin level (P < .0001), older recipient age (P = .04), and smaller recipient height (P = .02) were found to be associated with earlier graft loss in multivariate analysis. Moreover, pre-transplant corticosteroid treatment tended to be related to earlier graft loss (P = .06), while pulmonary hypertension did not significantly correlate. None of the pre-transplant variables were shown to be associated with CLAD development. Ongoing research is required to further explore this diverse patient population and the pre-transplant variables determining their post-transplant outcome. |
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Language
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English
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Source (journal)
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Clinical transplantation. - New York
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Publication
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New York
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2019
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ISSN
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0902-0063
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DOI
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10.1111/CTR.13661
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Volume/pages
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33
:10
(2019)
, 9 p.
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Article Reference
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e13661
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ISI
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000480035100001
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Pubmed ID
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31286560
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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