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Title
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Radiological analysis of unused donor lungs : a tool to improve donor acceptance for transplantation?
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Author
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Abstract
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| Despite donor organ shortage, a large proportion of possible donor lungs are declined for transplantation. Criteria for accepting/declining lungs remain controversial because of the lack of adequate tools to aid in decision-making. We collected, air-inflated, and froze a large series of declined/unused donor lungs and subjected these lung specimens to CT examination. Affected target regions were scanned by using micro-CT. Lungs from 28 donors were collected. Two lungs were unused, six were declined for non-allograft-related reasons (collectively denominated nonallograft declines, n = 8), and 20 were declined because of allograft-related reasons. CT scanning demonstrated normal lung parenchyma in only four of eight nonallograft declines, while relatively normal parenchyma was found in 12 of 20 allograft-related declines. CT and micro-CT examinations confirmed the reason for decline in most lungs and revealed unexpected (unknown from clinical files or physical inspection) CT abnormalities in other lungs. CT-based measurements showed a higher mass and density in the lungs with CT alterations compared with lungs without CT abnormalities. CT could aid in the decision-making to accept or decline donor lungs which could lead to an increase in the quantity and quality of lung allografts. |
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Language
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English
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Source (journal)
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American journal of transplantation. - Copenhagen
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Publication
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Copenhagen
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2017
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ISSN
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1600-6135
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DOI
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10.1111/AJT.14255
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Volume/pages
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17
:7
(2017)
, p. 1912-1921
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ISI
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000404372900027
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Pubmed ID
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28251829
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Full text (Publisher's DOI)
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