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Title
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Punching holes in cellular membranes : biology and evolution of gasdermins
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Author
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Abstract
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| The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease-and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates. |
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Language
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English
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Source (journal)
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Trends in cell biology. - Cambridge
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Publication
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London
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Elsevier science london
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2021
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ISSN
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0962-8924
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DOI
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10.1016/J.TCB.2021.03.004
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Volume/pages
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31
:6
(2021)
, p. 500-513
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ISI
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000651151800009
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Pubmed ID
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33771452
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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