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Title
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3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design
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Author
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Abstract
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| We report the use of 3-substituted 2-isocyanopyridines as convertible isocyanides in Ugi four-component reactions. The N-(3-substituted pyridin-2-yl)amide Ugi products can be cleaved by amines, alcohols, and water with Zn(OAc)(2) as a catalyst. In addition, the applicability of the method was demonstrated in constrained di-/tripeptides bearing acid and base sensitive protective groups obtained via Ugi-4CR post-condensation modifications. |
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Language
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English
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Source (journal)
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Chemical communications / Royal Society of Chemistry [London] - London, 1996, currens
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Publication
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Cambridge
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Royal soc chemistry
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2021
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ISSN
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1359-7345
[print]
1364-548X
[online]
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DOI
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10.1039/D1CC01701B
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Volume/pages
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57
:56
(2021)
, p. 6863-6866
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ISI
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000661587100001
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Pubmed ID
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34132258
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Full text (Publisher's DOI)
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Full text (open access)
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