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Title
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Multi-analyte LC-MS/MS quantification of 38 antipsychotics and metabolites in plasma : method validation & application to routine analyses
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Author
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Abstract
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| The past decades have seen a rise in the prescription of antipsychotic drugs in the European population, despite the risk of extra-pyramidal, metabolic and cardiac side effects. A multi-analyte liquid chromatography – triple quadrupole mass spectrometry method was developed for the quantification of 38 antipsychotic drugs in plasma. Samples were extracted by a straightforward liquid–liquid extraction with methyl-tertiary-butyl-ether and the compounds of interest were chromatographically separated within 6 min. Calibration curves covered the recommended therapeutic range for all compounds, in addition to sub- and supratherapeutic concentrations for most. The method was successfully validated according to the European Medicines Agency guidelines on bioanalytical method validation. Analysis of medico-legal samples confirmed the relatively common use of the second generation antipsychotics quetiapine and olanzapine, as well as the continued presence of the first generation antipsychotic haloperidol. |
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Language
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English
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Source (journal)
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Journal of chromatography : B: analytical technologies in the biomedical and life sciences. - Amsterdam, 2002, currens
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Publication
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Amsterdam
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Elsevier
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2021
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ISSN
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1570-0232
[print]
1873-376X
[online]
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DOI
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10.1016/J.JCHROMB.2021.122867
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Volume/pages
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1179
(2021)
, 7 p.
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Article Reference
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122867
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ISI
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000687831200007
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Pubmed ID
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34333215
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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