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Title
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Measuring viscoelastic parameters in Magnetic Resonance Elastography : a comparison at high and low magnetic field intensity
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Author
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Abstract
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| Magnetic Resonance Elastography (MRE) is a non-invasive imaging technique which involves motion-encoding MRI for the estimation of the shear viscoelastic properties of soft tissues through the study of shear wave propagation. The technique has been found informative for disease diagnosis, as well as for monitoring of the effects of therapies. The development of MRE and its validation have been supported by the use of tissuemimicking phantoms. In this paper we present our new MRE protocol using a low magnetic field tabletop MRI device at 0.5 T and sinusoidal uniaxial excitation in a geometrical focusing condition. Results obtained for gelatin are compared to those previously obtained using high magnetic field MRE at 11.7 T. A multi-frequency investigation is also provided via a comparison of commonly used rheological models: Maxwell, Springpot, Voigt, Zener, Jeffrey, fractional Voigt and fractional Zener. Complex shear modulus values were comparable when processed from images acquired with the tabletop low field scanner and the high field scanner. This study serves as a validation of the presented tabletop MRE protocol and paves the way for MRE experiments on ex-vivo tissue samples in both normal and pathological conditions. |
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Language
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English
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Source (journal)
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Journal of the mechanical behavior of biomedical materials. - Place of publication unknown
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Publication
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Place of publication unknown
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2021
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ISSN
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1751-6161
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DOI
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10.1016/J.JMBBM.2021.104587
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Volume/pages
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120
(2021)
, 9 p.
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Article Reference
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104587
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ISI
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000663147000004
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Pubmed ID
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34034077
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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