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Title
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From suspect screening to target analysis : occurrence of six newly identified compounds in indoor dust from Belgium
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Author
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Abstract
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| Six newly identified compounds, dimethyl azelate (DMA), dimethyl sebacate (DMS), di-propylene glycol dibenzoate (DiPGDB), tri-n-butyl trimellitate (TBTM), isooctyl 2-phenoxyethyl terephthalate (IOPhET) and bis3,5,5-trimethylhexyl phosphate (TMHPh), were quantified in residential dust using a modified and in-house validated method. The method was based on vortex and ultrasonic extraction, Florisil fractionation and liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis. Fifty paired dust samples were collected from homes located in the Flemish region of Belgium, during winter (n = 25) and summer (n = 25) of 2019. Method LOQs ranged between 3.8 and 94 ng/g. The ranges of total concentrations of targeted compounds were 0.6-89 mu g/g for winter and 0.8-130 mu g/g for summer samples. DiPGDB was the dominant compound, with 88% and 92% contribution in dust samples per season, followed by TBTM > TMHPh > DMA (less than 10% contribution in both seasons) and DMS, detected only in the summer samples. Human exposure was evaluated for inadvertent dust ingestion using the oral derived no effects level values (DNEL) where available in ECHA, for (I) the hypothesis, where the total concentration of the chemical is considered bio-accessible, (II) the hypothesis where the bio-accessible fraction is defined by the theoretical bio-accessibility, calculated based on logKow values. In both scenarios, DiPGDB, TBTM and TMHPh had the most important contribution to human exposure, with toddlers being more exposed than adults. No risk for adverse human health effects was derived from the comparison with DNELs. |
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Language
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English
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Source (journal)
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Environmental research. - Amsterdam, 1967, currens
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Publication
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Amsterdam
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Elsevier
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2021
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ISSN
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0013-9351
[print]
1096-0953
[online]
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DOI
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10.1016/J.ENVRES.2021.111193
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Volume/pages
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197
(2021)
, 9 p.
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Article Reference
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111193
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ISI
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000663718100013
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Pubmed ID
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33901444
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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