|
Title
|
|
|
|
Glucose control using fast‐acting insulin aspart in a real‐world setting : a 1‐year, two‐centre study in people with type 1 diabetes using continuous glucose monitoring
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Aim To evaluate the efficacy and safety of switching from traditional mealtime insulins to fast-acting insulin aspart (Fiasp) in a “real-world” clinical practice setting in adult people with type 1 diabetes (PWD1) who were using intermittently scanned or real-time continuous glucose monitoring (isCGM or rtCGM, respectively). Materials and Methods Data from 438 adult PWD1 (60% men, age 44.6 ± 16.2 years, diabetes duration 21.5 ± 14.0 years, isCGM/rtCGM: 391/47, multiple daily injections/continuous subcutaneous insulin infusion: 409/29), who initiated Fiasp from January 2018 to May 2020, were analysed. The primary objective was the evolution of time in range (TIR; 70-180 mg/dL) at 6 and 12 months. Secondary objectives included change in HbA1c, body mass index (BMI), insulin doses, time below range (<70 and <54 mg/dL), and time above range (>180 and >250 mg/dL). Results TIR improved from 50.3% ± 15.6% to 54.3% ± 15.1% at 6 months (n = 425) and to 55.5% ± 15.2% at 12 months (n = 385) (P < .001), corresponding to 57 min/d at 6 months and 75 min/d at 12 months. Time spent below 54 mg/dL evolved from 3.1% ± 3.3% to 3.1% ± 3.7% and 2.5% ± 3.0% at 6 and 12 months, respectively (P = .011). Also, time spent above 180 mg/dL decreased from 42.3% ± 16.7% at start by 4.2% at 6 months and by 4.6% at 12 months (P < .001). The proportion of people reaching TIR more than 70% increased from 11.0% to 14.8% (P = .002), and those spending less than 4% at time less than 70 mg/dL increased from 36.1% to 42.1% (P = .002). After 12 months, HbA1c, insulin doses, and BMI did not change significantly. Conclusions In a Belgian real-world setting of adult PWD1, switching to Fiasp was associated with a 5% increased TIR after 12 months, corresponding to 75 min/d, in combination with less time spent below and above range. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Diabetes, obesity & metabolism. - Oxford, 1999, currens
| |
|
Publication
|
|
|
|
Oxford
:
Blackwell
,
2021
| |
|
ISSN
|
|
|
|
1462-8902
[print]
1463-1326
[online]
| |
|
DOI
|
|
|
|
10.1111/DOM.14527
| |
|
Volume/pages
|
|
|
|
23
:12
(2021)
, p. 2716-2727
| |
|
Article Reference
|
|
|
|
dom.14527
| |
|
ISI
|
|
|
|
000688339100001
| |
|
Pubmed ID
|
|
|
|
34402157
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (publisher's version - intranet only)
|
|
|
|
| |
|