Publication
Title
Antiproliferative activity of ester derivatives of monensin A at the C-1 and C-26 positions
Author
Abstract
Monensin A (MON) is a polyether ionophore antibiotic, which shows a wide spectrum of biological activity, including anticancer activity. A series of structurally diverse monensin esters including its C-1 esters (1-9), C-26-O-acetylated derivatives (10-15), and lactone (16) was synthesized and for the first time evaluated for their antiproliferative activity against four human cancer cell lines with different drug-sensitivity level. All of the MON derivatives exhibited in vitro antiproliferative activity against cancer cells at micromolar concentrations. The majority of the compounds was able to overcome the drug resistance of LoVo/DX and MES-SA/DX5 cell lines. The most active compounds proved to be MON C-26-O-acetylated derivatives (10-15) which exhibited very good resistance index and high selectivity index.
Language
English
Source (journal)
Chemical biology and drug design. - Copenhagen, 2006, currens
Publication
Copenhagen : 2019
ISSN
1747-0277 [print]
1747-0285 [online]
DOI
10.1111/CBDD.13581
Volume/pages
94 :4 (2019) , p. 1859-1864
ISI
000477433500001
Pubmed ID
31260603
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 27.09.2021
Last edited 29.08.2024
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