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Title
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Synthesis and antiproliferative activity of silybin conjugates with salinomycin and Monensin
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Author
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Abstract
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| Aiming at development of multitarget drugs for the anticancer treatment, new silybin (SIL) conjugates with salinomycin (SAL) and monensin (MON) were synthesized, in mild esterification conditions, and their antiproliferative activity was studied. The conjugates obtained exhibit anticancer activity against HepG2, LoVo and LoVo/DX cancer cell lines. Moreover, MON-SIL conjugate exhibits higher anticancer potential and better selectivity than the corresponding SAL-SIL conjugate. |
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Language
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English
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Source (journal)
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Chemical biology and drug design. - Copenhagen, 2006, currens
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Publication
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Copenhagen
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2015
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ISSN
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1747-0277
[print]
1747-0285
[online]
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DOI
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10.1111/CBDD.12602
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Volume/pages
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86
:6
(2015)
, p. 1378-1386
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ISI
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000367376800006
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Pubmed ID
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26058448
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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