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Title
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Anti-proliferative activity of Monensin and its tertiary amide derivatives
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Author
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Abstract
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| New tertiary amide derivatives of polyether ionophore Monensin A (MON) were synthesised and their anti-proliferative activity against cancer cell lines was studied. Very high activity (IC50 = 0.09 mu M) and selectivity (SI = 232) of MON against human biphenotypic myelomonocytic leukemia cell line (MV4-11) was demonstrated. The MON derivatives obtained exhibit interesting anti-proliferative activity, high selectivity index and also are able to break the drug-resistance of cancer cell line. (C) 2015 Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Bioorganic and medicinal chemistry letters. - Oxford
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Publication
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Oxford
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2015
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ISSN
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0960-894X
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DOI
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10.1016/J.BMCL.2015.08.067
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Volume/pages
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25
:20
(2015)
, p. 4539-4543
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ISI
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000362102200032
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Pubmed ID
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26338363
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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