Quality assurance of the EORTC 22043-30041 trial in post-operative radiotherapy in prostate cancer : results of the Dummy Run procedure

Fenton, Paul A.; Hurkmans, Coen; Gulyban, Akos; van der Leer, Jorien; Matzinger, Oscar; Poortmans, Philip; Collette, Laurence; Bolla, Michel

doi:10.1016/J.RADONC.2013.04.020

Title

Quality assurance of the EORTC 22043-30041 trial in post-operative radiotherapy in prostate cancer : results of the Dummy Run procedure

Author

Fenton, Paul A.

Hurkmans, Coen

Gulyban, Akos

van der Leer, Jorien

Matzinger, Oscar

Poortmans, Philip

Collette, Laurence

Bolla, Michel

Abstract

Background and purpose: The EORTC 22043-30041 trial investigates the role of the addition of androgen suppression to post-operative radiotherapy in patients who have undergone radical prostatectomy. As part of the quality assurance of radiotherapy (QART) a Dummy Run (DR) procedure was performed. Materials and method: The protocol included detailed and published delineation guidelines. Participating institutions digitally submitted radiotherapy treatment volumes and a treatment plan for a standard clinical case. Submissions were centrally reviewed using the VODCA software platform. Results: Thirty-eight submissions from thirty-one institutions were reviewed. Six were accepted without comments. Twenty-three were accepted with comments on one or more items: target volume delineation (22), OAR delineation (23), planning and dosimetry (3) or treatment verification (1). Nine submissions were rejected requiring resubmission, seven for target volume delineation reasons alone. Intervention to highlight the importance of delineation guidelines was made prior to the entry of the first patient in the trial. After this, a lower percentage of resubmissions was required. Conclusions: The EORTC 22043-30041 Dummy Run highlights the need for timely and effective QART in clinical trials. The variation in target volume and OAR definition demonstrates that clinical guidelines and radiotherapy protocols are not a substitute for QART procedures. Early intervention in response to the Dummy Run improved protocol understanding. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

Language

English

Source (journal)

Radiotherapy and oncology. - Amsterdam

Publication

Amsterdam : 2013

ISSN

0167-8140

DOI

10.1016/J.RADONC.2013.04.020

Volume/pages

107 :3 (2013) , p. 346-351