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Title
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The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy
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Author
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Abstract
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| Background: Neoadjuvant chemotherapy (NAG) is increasingly used in the framework of breast-conserving therapy (BCT). Localization of the initial tumor is essential to guide surgical resection after NAG. This study describes the results obtained with I-125 seed localization in BCT including NAG. Patients and methods: Between January 2009 and December 2010, 85 patients treated with NAG and BCT after I-125 seed localization were included. Radiological and pathological response and resection margins were retrospectively evaluated. Results: BCT was carried out in 85 patients without secondary local excisions. Nineteen patients with unifocal tumors and seven patients with multifocal tumors showed a complete pathological response (P = 0.18). Tumor-free resection margins were obtained in 78 patients (50 patients with unifocal and 28 patients with multifocal tumors, P = 0.27). Focally involved margins were found in four patients (two patients with a unifocal and two patients with a multifocal tumor, P = 0.27). A subsequent mastectomy was carried out in three patients (two patients with multifocal tumors, P = 0.29). Conclusions: BCT after NAC can be carried out successfully after initial localization with I-125 seeds in both unifocal and multifocal breast tumors with complete resection rates of >90%. |
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Language
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English
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Source (journal)
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Annals of oncology / European Society for Medical Oncology. - Amsterdam
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Publication
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Amsterdam
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2013
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ISSN
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0923-7534
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DOI
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10.1093/ANNONC/MDS475
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Volume/pages
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24
:3
(2013)
, p. 668-673
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ISI
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000316504900013
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Pubmed ID
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23139261
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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