Quality assurance for prospective EORTC radiation oncology trials : the challenges of advanced technology in a multicenter international setting

Weber, Damien C.; Poortmans, Philip M.P.; Hurkmans, Coen W.; Aird, Edwin; Gulyban, Akos; Fairchild, Alysa

doi:10.1016/J.RADONC.2011.05.073

Title

Quality assurance for prospective EORTC radiation oncology trials : the challenges of advanced technology in a multicenter international setting

Author

Weber, Damien C.

Poortmans, Philip M.P.

Hurkmans, Coen W.

Aird, Edwin

Gulyban, Akos

Fairchild, Alysa

Abstract

The European Organization for the Research and Treatment of Cancer (EORTC) is a pan-European structure charged with improving cancer treatment through the testing of new therapeutic strategies in phases I-III clinical studies. Properly conducted trials in radiation oncology are required to demonstrate superiority of a new treatment over the current standard. The Radiation Oncology Group (ROG) has initiated a complex quality assurance (QA) program to ensure safe and effective treatment delivery. Most modern trials are multicenter and multidisciplinary, further increasing the importance of early, strict and consistent QA in radiotherapy (RT). QART measures confirm whether a site possesses minimum staff and equipment for participation. Dummy runs, reviews of patient treatment plans and complex dosimetry checks verify the ability of an institution to comply with the protocol. Data required for evaluation are increasingly exchanged digitally, allowing detailed plan reconstruction, evaluation of target volume delineation and recalculation of dose-volume parameters for comparison against predefined standards. The five tiers of QA implemented in EORTC trials are reviewed, along with past, current and future QART initiatives. As substantial human and financial resources are increasingly invested in QART, the importance of cost-benefit analysis of QA and its impact on clinical outcome cannot be overstated. (c) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 100 (2011) 150-156

Language

English

Source (journal)

Radiotherapy and oncology. - Amsterdam

Publication

Clare : Elsevier ireland ltd , 2011

ISSN

0167-8140

DOI

10.1016/J.RADONC.2011.05.073

Volume/pages

100 :1 (2011) , p. 150-156