EORTC-ROG expert opinion : radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach

Matzinger, Oscar; Gerber, Erich; Bernstein, Zvi; Maingon, Philippe; Haustermans, Karin; Bosset, Jean Francois; Gulyban, Akos; Poortmans, Philip; Collette, Laurence; Kuten, Abraham

doi:10.1016/J.RADONC.2009.03.018

Title

EORTC-ROG expert opinion : radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach

Author

Matzinger, Oscar

Gerber, Erich

Bernstein, Zvi

Maingon, Philippe

Haustermans, Karin

Bosset, Jean Francois

Gulyban, Akos

Poortmans, Philip

Collette, Laurence

Kuten, Abraham

Abstract

Purpose: The Gastro-Intestinal Working Party of the EORTC Radiation Oncology Group (GIWP-ROG) developed guidelines for target volume definition in neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction (GEJ) and the stomach. Methods and materials: Guidelines about the definition of the clinical target volume (CTV) are based on a systematic literature review of the location and frequency of local recurrences and lymph node involvement in adenocarcinomas of the GEJ and the stomach. Therefore, MEDLINE was searched up to August 2008. Guidelines concerning prescription, planning and treatment delivery are based on a consensus between the members of the GIWP-ROG. Results: In order to support a curative resection of GEJ and gastric cancer, an individualized preoperative treatment volume based on tumour location has to include the primary tumour and the draining regional lymph nodes area. Therefore we recommend to use the 2nd English Edition of the Japanese Classification of Gastric Carcinoma of the Japanese Gastric Cancer Association which developed the concept of assigning tumours of the GEJ and the stomach to anatomically defined sub-sites corresponding respectively to a distinct lymphatic spread. pattern. Conclusion: The GIWP-ROG defined guidelines for preoperative irradiation of adenocarcinomas of the GEJ and the stomach to reduce variability in the framework of future clinical trials. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 92 (2009) 164-175

Language

English

Source (journal)

Radiotherapy and oncology. - Amsterdam

Publication

Amsterdam : 2009

ISSN

0167-8140

DOI

10.1016/J.RADONC.2009.03.018

Volume/pages

92 :2 (2009) , p. 164-175