|
Title
|
|
|
|
Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer : a study based on the EORTC trial 22881-10882 'boost versus no boost'
| |
|
Author
|
|
|
|
| |
|
Institution/Organisation
|
|
|
|
EORTC Radiation Oncology Group
| |
|
Abstract
|
|
|
|
| The EORTC 22881-10882 trial in 5178 conservatively treated early breast cancer patients showed that a 16 Gy boost dose significantly improved local control, but increased the risk of breast fibrosis. To investigate predictors for the long-term risk of fibrosis, Cox regression models of the time to moderate or severe fibrosis were developed on a random set of 1797 patients with and 1827 patients without a boost, and validated in the remaining set. The median follow-up was 10.7 years. The risk of fibrosis significantly increased (P < 0.01) with increasing maximum whole breast irradiation (WBI) dose and with concomitant chernotherapy, but was independent of age. In the boost arm, the risk further increased (P < 0.01) if patients had post-operative breast oedema or haematoma, but it decreased (P < 0.01) if WBI was given with >6 MV photons. The c-index was around 0.62. Nomograms with these factors are proposed to forecast the long-term risk of moderate or severe fibrosis. (C) 2008 Elsevier Ltd. All rights reserved. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
European journal of cancer. - Oxford, 1990, currens
| |
|
Publication
|
|
|
|
Oxford
:
2008
| |
|
ISSN
|
|
|
|
0959-8049
[print]
1879-0852
[online]
| |
|
DOI
|
|
|
|
10.1016/J.EJCA.2008.07.032
| |
|
Volume/pages
|
|
|
|
44
:17
(2008)
, p. 2587-2599
| |
|
ISI
|
|
|
|
000261562700014
| |
|
Pubmed ID
|
|
|
|
18757193
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (publisher's version - intranet only)
|
|
|
|
| |
|