A population based study of radiotherapy in a cohort of patients with breast cancer diagnosed between 1996 and 2000

Vulto, J.C.M.; Louwman, W.J.; Poortmans, P.M.P.; Lybeert, L.M.; Rutten, H.J.T.; Coebergh, J.W.W.

doi:10.1016/J.EJCA.2007.05.020

Title

A population based study of radiotherapy in a cohort of patients with breast cancer diagnosed between 1996 and 2000

Author

Vulto, J.C.M.

Louwman, W.J.

Poortmans, P.M.P.

Lybeert, L.M.

Rutten, H.J.T.

Coebergh, J.W.W.

Abstract

We studied the use of radiotherapy (RT) (especially secondary RT) in a cohort of 6561 patients in southern Netherlands with invasive breast cancer diagnosed between 1996 and 2000 (median follow-up: 66 months, range 0-107 months). Radiation within 6 months of diagnosis was considered primary RT (PRT). RT given 6 months or later after diagnosis or after PRT was considered secondary RT (SRT). Of all patients, 67% received RT, 3554 only PRT, 323 only SRT and 503 both. The cumulative use of SRT at 100 months was 17%. The 826 patients receiving SRT underwent 1846 courses 0-105 months (median 36) after diagnosis; the retreat rate was 35%. Elderly patients received SRT significantly less often (ORage50-69 = 0.7, 95%CI = 0.6-0.8, ORage >= 70 = 0.4, 95%CI = 0.3-0.5). The following factors increased the chance for SRT. patients from the eastern region (OR = 1.3, 95%CI = 1.1-1.6); patients who received PRT (OR = 1.3, 95%CI = 1.0-1.5) and patients who underwent mastectomy including axillary node dissection as well as unresected patients (OR = 1.9, 95%CI = 1.5-2.4, OR = 2.6, 95%CI = 1.7-3.9, respectively). Thirteen percent of all patients with breast cancer received SRT, with a large variation in age and between the 2 RT departments in the region. (C) 2007 Elsevier Ltd. All rights reserved.

Language

English

Source (journal)

European journal of cancer. - Oxford, 1990, currens

Publication

Oxford : 2007

ISSN

0959-8049 [print]

1879-0852 [online]

DOI

10.1016/J.EJCA.2007.05.020

Volume/pages