Publication
Title
Ouality assurance in the EORTC randomized trial 22922/10925 investigating the role of irradiation of the internal mammary and medial supraclavicular lymph node chain works = Qualitätskontrolle in der randomisierten EORTC-Studie 22922/10925 über die Rolle der Radiotherapie bei der Behandlung der Mammaria-interna-und der supraklavikulären Lymphknoten
Author
Institution/Organisation
EORTC Radiation Oncology and Breast Cancer Groups
Abstract
Background and Purpose: A quality assurance (QA) program in conjunction with the EORTC trial investigating the rote of adjuvant internal mammary and medial. supraclavicular irradiation in stage I-III breast cancer is presented. The results of a dummy run procedure and of an individual case review are compared to each other. The effects of recommendations based on QA procedures on the protocol compliance are evaluated. Material and Methods: Prior to protocol activation all participating institutes were asked to produce treatment plans according to the guidelines of the protocol based on manual outlines of an average patient. Thereafter, they were asked to provide data on each of their first six randomized patients. Results: The dummy run provided a lot of information on specific treatment techniques. In the individual case review, additional patient- and tumor-related data were collected, showing the use of anatomic information for treatment planning. A comparison between both procedures revealed that the individual case reports concurred more accurately with protocol guidelines than the dummy run. Conclusion: It was observed that the number of systematic protocol deviations was substantially decreased in trial patients compared to the dummy run case. Therefore, it is concluded that this extensive QA program had a positive effect on the consistency of all institutes participating in the trial.
Language
English
Source (journal)
Strahlentherapie und Onkologie. - München, 1986, currens
Publication
München : 2006
ISSN
0179-7158 [print]
1439-099X [online]
DOI
10.1007/S00066-006-1629-2
Volume/pages
182 :10 (2006) , p. 576-582
ISI
000241240600002
Pubmed ID
17013570
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 08.11.2021
Last edited 27.12.2024
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