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Title
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Targeting multiple myeloma through protein kinase and ferroptosis therapeutics
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Author
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Abstract
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| Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation of a clone of malignant plasma cells in the bone marrow. Despite recent advances in treatment regimens, MM remains an incurable disease with conventional therapies, such as proteasome inhibitors, immunomodulatory drugs, corticosteroids, and alkylating agents only resulting in low remission rates and limited survival times. This treatment failure of existing anti-cancer drugs can be explained by the development of (acquired) multi-drug resistance, which renders cancer cells cross-resistant to structurally and functionally unrelated drugs. Due to the multifactorial nature of the molecular mechanisms involved in acquisition of therapy resistance, it remains challenging to develop effective, curative treatments for MM. Thus, there is an urgent need to explore novel therapeutic strategies to achieve complete and persistent tumor remission in MM patients. In this PhD thesis work, we explored kinase inhibition, treatment with natural compounds, and ferroptosis induction as alternative therapy strategies to overcome MM drug resistance. |
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Language
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English
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Publication
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Antwerp
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University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Department Biomedical Sciences
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2021
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Volume/pages
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254 p.
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Note
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Vanden Berghe, Wim [Supervisor]
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Full text (open access)
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