Publication
Title
Validation of liquid biopsy for ESR1-mutation analysis in hormone-sensitive breast cancer : a pooled meta-analysis
Author
Abstract
Several retrospective and prospective studies have shown that genomic alterations in Estrogen-receptor one (ESR1) can be characterized not only in tissue samples but also by sequencing circulating tumor DNA (ctDNA) in liquid biopsy. Therefore, liquid biopsy is a potential noninvasive surrogate for tissue biopsy. This meta-analysis was designed to compare the prevalence of ESR 1 mutation detected with liquid biopsy and tissue biopsy. A pooled meta-analysis of studies published between 1 January 2007 and 1 March 2021 was conducted regarding the methodologies used for ESR1 mutation analysis. Liquid biopsy is a valid, inexpensive, and attractive noninvasive alternative to tumor biopsies for the identification of ESR1 mutations. Liquid biopsy for ESR 1 analysis would facilitate regular testing, allowing monitoring of the sensitivity to ET and guiding treatment strategies.
Language
English
Source (journal)
Frontiers in oncology / Frontiers Research Foundation (Lausanne, Switzerland) - [Lausanne, 2011, currens
Publication
Lausanne : Frontiers media sa , 2023
ISSN
2234-943X
DOI
10.3389/FONC.2023.1221773
Volume/pages
13 (2023) , p. 1-12
Article Reference
1221773
ISI
001058494700001
Pubmed ID
37675216
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 08.12.2024
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