Publication
Title
The RSVPreF3-AS01 vaccine elicits broad neutralization of contemporary and antigenically distant respiratory syncytial virus strains
Author
Abstract
Ruping Sun, Jason M. Sheltzer* INTRODUCTION: It has been known for more than 100 years that human cancers exhibit pervasive aneuploidy, or chromosome copy number changes. For instance, about 25% of cancers exhibit gains of the q arm of chromosome 1. However, despite the prevalence of aneuploidy across cancer types, its role in cancer is dependent on the expression of an individual oncogene for continued malignant growth, and loss or inhibition of that oncogene is sufficient to induce cancer regression. As specific aneuploidies such as the gain of chromosome 1q are frequent events in diverse cancer types, we hypothesized that certain An analysis of clinical sequencing onstrated that chromosome early during tumorigenesis and exclusive with mutations in the pressor 7P53 , suggesting that could represent a mutation-independent nism for blocking p53 signaling. with this, we demonstrated mediated elimination of chromosome somies increased the expression
Language
English
Source (journal)
Science translational medicine. - -
Publication
2023
ISSN
1946-6234
DOI
10.1126/SCITRANSLMED.ADG6050
Volume/pages
15 :710 (2023) , p. 1-13
Article Reference
eadg6050
ISI
001057210400004
Pubmed ID
37611082
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 02.02.2024
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