|
Title
|
|
|
|
The RSVPreF3-AS01 vaccine elicits broad neutralization of contemporary and antigenically distant respiratory syncytial virus strains
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Ruping Sun, Jason M. Sheltzer* INTRODUCTION: It has been known for more than 100 years that human cancers exhibit pervasive aneuploidy, or chromosome copy number changes. For instance, about 25% of cancers exhibit gains of the q arm of chromosome 1. However, despite the prevalence of aneuploidy across cancer types, its role in cancer is dependent on the expression of an individual oncogene for continued malignant growth, and loss or inhibition of that oncogene is sufficient to induce cancer regression. As specific aneuploidies such as the gain of chromosome 1q are frequent events in diverse cancer types, we hypothesized that certain An analysis of clinical sequencing onstrated that chromosome early during tumorigenesis and exclusive with mutations in the pressor 7P53 , suggesting that could represent a mutation-independent nism for blocking p53 signaling. with this, we demonstrated mediated elimination of chromosome somies increased the expression |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Science translational medicine. - -
| |
|
Publication
|
|
|
|
2023
| |
|
ISSN
|
|
|
|
1946-6234
| |
|
DOI
|
|
|
|
10.1126/SCITRANSLMED.ADG6050
| |
|
Volume/pages
|
|
|
|
15
:710
(2023)
, p. 1-13
| |
|
Article Reference
|
|
|
|
eadg6050
| |
|
ISI
|
|
|
|
001057210400004
| |
|
Pubmed ID
|
|
|
|
37611082
| |
|
Medium
|
|
|
|
E-only publicatie
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|