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Title
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Chemical probes for profiling of MALT1 protease activity
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Author
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Abstract
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| The paracaspase MALT1 is a key regulator of the human immune response. It is implicated in a variety of human diseases. For example, deregulated protease activity drives the survival of malignant lymphomas and is involved in the pathophysiology of autoimmune/inflammatory diseases. Thus, MALT1 has attracted attention as promising drug target. Although many MALT1 inhibitors have been identified, molecular tools to study MALT1 activity, target engagement and inhibition in complex biological samples, such as living cells and patient material, are still scarce. Such tools are valuable to validate MALT1 as a drug target in vivo and to assess yet unknown biological roles of MALT1. In this review, we discuss the recent literature on the development and biological application of molecular tools to study MALT1 activity and inhibition. MALT1 is a cysteine protease and the only human paracaspase. It is implicated in various human diseases. Here, an overview of the currently available molecular tools is given. Furthermore, their application and future possibilities are discussed. We expect that future research with these and improved tools will provide novel insights into MALT1's pathobiological roles and enable use as diagnostic tools.image |
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Language
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English
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Source (journal)
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ChemBioChem: a European journal of chemical biology. - Weinheim
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Publication
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Weinheim
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Wiley-v c h verlag gmbh
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2023
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ISSN
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1439-4227
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DOI
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10.1002/CBIC.202300444
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Volume/pages
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24
:21
(2023)
, p. 1-14
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Article Reference
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e202300444
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ISI
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001066072100001
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Pubmed ID
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37607867
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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