Publication
Title
Chemical probes for profiling of MALT1 protease activity
Author
Abstract
The paracaspase MALT1 is a key regulator of the human immune response. It is implicated in a variety of human diseases. For example, deregulated protease activity drives the survival of malignant lymphomas and is involved in the pathophysiology of autoimmune/inflammatory diseases. Thus, MALT1 has attracted attention as promising drug target. Although many MALT1 inhibitors have been identified, molecular tools to study MALT1 activity, target engagement and inhibition in complex biological samples, such as living cells and patient material, are still scarce. Such tools are valuable to validate MALT1 as a drug target in vivo and to assess yet unknown biological roles of MALT1. In this review, we discuss the recent literature on the development and biological application of molecular tools to study MALT1 activity and inhibition. MALT1 is a cysteine protease and the only human paracaspase. It is implicated in various human diseases. Here, an overview of the currently available molecular tools is given. Furthermore, their application and future possibilities are discussed. We expect that future research with these and improved tools will provide novel insights into MALT1's pathobiological roles and enable use as diagnostic tools.image
Language
English
Source (journal)
ChemBioChem: a European journal of chemical biology. - Weinheim
Publication
Weinheim : Wiley-v c h verlag gmbh , 2023
ISSN
1439-4227
DOI
10.1002/CBIC.202300444
Volume/pages
24 :21 (2023) , p. 1-14
Article Reference
e202300444
ISI
001066072100001
Pubmed ID
37607867
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 25.04.2024
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