Clinical outcomes and epidemiological characteristics of bacteremia in the older Japanese population

Nakamura, Keiji; Hayakawa, Kayoko; Tsuzuki, Shinya; Ide, Satoshi; Nomoto, Hidetoshi; Nakamoto, Takato; Yamada, Gen; Yamamoto, Kei; Ohmagari, Norio

doi:10.1016/J.JIAC.2023.06.015

Title

Clinical outcomes and epidemiological characteristics of bacteremia in the older Japanese population

Author

Nakamura, Keiji

Hayakawa, Kayoko

Tsuzuki, Shinya

Ide, Satoshi

Nomoto, Hidetoshi

Nakamoto, Takato

Yamada, Gen

Yamamoto, Kei

Ohmagari, Norio

Abstract

Background: The characteristics and clinical consequences of bacteremia in older people, who are highly susceptible to infections, need to be clarified. This study aimed to determine the epidemiological characteristics, prognosis, and predictors of 7-day mortality in patients with community-acquired (CA), healthcare-associated (HCA), and hospital-onset (HO) bacteremia in older adults aged =65 years.Methods: Patients aged =65 years with positive blood cultures between April 1, 2015, and March 31, 2018, were divided into three groups: pre-old (65-74 years), old (75-89 years), and super-old (=90 years). Characteristics based on medical exposure, including CA, HCA, and HO, were also compared and factors related to mortality were identified.Results: Overall, 1716 episodes of bacteremia were identified in 1415 patients. Of the 1211 episodes without contamination, 32.8%, 54.3%, and 12.9% occurred in pre-old, old, and super-old patients. Central line-associated bloodstream infections were more common in pre-old patients and urinary tract infections in the old and super old. The 7-day mortality rates in the pre-old, old, and super-old groups were 7.4%, 5.8%, and 14.2% (P = 0.002), respectively. Multivariable logistic regression showed that super-old age (adjusted odds ratio, aOR: 2.09 [1.13-3.88], P = 0.019) and HO bacteremia (aOR: 1.97 [1.18-3.28], P = 0.010) were independent risk factors for 7-day mortality. Infectious disease consultation had a protective effect on 7-day mortality (aOR: 0.59 [0.35-0.99], P = 0.047).Conclusions: The epidemiology of bacteremia differs among older people; thus, they should not be treated as a single entity. A careful approach is needed for the optimal management of bacteremia in these vulnerable patients.

Language

English

Source (journal)

Journal of infection and chemotherapy. - Tokyo, 1995, currens

Publication

Tokyo : 2023

ISSN

1341-321X [print]

1437-7780 [online]

DOI

10.1016/J.JIAC.2023.06.015

Volume/pages