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Title
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Reviewing the neurobiology of electroconvulsive therapy on a micro- meso-and macro-level
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Author
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Abstract
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| Background: Electroconvulsive therapy (ECT) remains the one of the most effective of biological antidepressant interventions. However, the exact neurobiological mechanisms underlying the efficacy of ECT remain unclear. A gap in the literature is the lack of multimodal research that attempts to integrate findings at different biological levels of analysisMethods: We searched the PubMed database for relevant studies. We review biological studies of ECT in depression on a micro-(molecular), meso-(structural) and macro-(network) level. Results: ECT impacts both peripheral and central inflammatory processes, triggers neuroplastic mechanisms and modulates large scale neural network connectivity.Conclusions: Integrating this vast body of existing evidence, we are tempted to speculate that ECT may have neuroplastic effects resulting in the modulation of connectivity between and among specific large-scale networks that are altered in depression. These effects could be mediated by the immunomodulatory properties of the treatment. A better understanding of the complex interactions between the micro-, meso-and macro-level might further specify the mechanisms of action of ECT. |
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Language
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English
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Source (journal)
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Progress in neuro-psychopharmacology and biological psychiatry. - Oxford
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Publication
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Oxford
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2023
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ISSN
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0278-5846
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DOI
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10.1016/J.PNPBP.2023.110809
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Volume/pages
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127
(2023)
, p. 1-11
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Article Reference
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110809
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ISI
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001058413700001
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Pubmed ID
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37331685
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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