Publication
Title
Reviewing the neurobiology of electroconvulsive therapy on a micro- meso-and macro-level
Author
Abstract
Background: Electroconvulsive therapy (ECT) remains the one of the most effective of biological antidepressant interventions. However, the exact neurobiological mechanisms underlying the efficacy of ECT remain unclear. A gap in the literature is the lack of multimodal research that attempts to integrate findings at different biological levels of analysisMethods: We searched the PubMed database for relevant studies. We review biological studies of ECT in depression on a micro-(molecular), meso-(structural) and macro-(network) level. Results: ECT impacts both peripheral and central inflammatory processes, triggers neuroplastic mechanisms and modulates large scale neural network connectivity.Conclusions: Integrating this vast body of existing evidence, we are tempted to speculate that ECT may have neuroplastic effects resulting in the modulation of connectivity between and among specific large-scale networks that are altered in depression. These effects could be mediated by the immunomodulatory properties of the treatment. A better understanding of the complex interactions between the micro-, meso-and macro-level might further specify the mechanisms of action of ECT.
Language
English
Source (journal)
Progress in neuro-psychopharmacology and biological psychiatry. - Oxford
Publication
Oxford : 2023
ISSN
0278-5846
DOI
10.1016/J.PNPBP.2023.110809
Volume/pages
127 (2023) , p. 1-11
Article Reference
110809
ISI
001058413700001
Pubmed ID
37331685
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Preventing Relapse After Successful ECT for Depression– A randomized controlled trial on lithium as add-on to personalized maintenance ECT.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 28.01.2024
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