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Title
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Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials
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Author
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Abstract
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| With the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safety of cell- and tissue and organ donation. The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting. |
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Language
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English
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Source (journal)
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Cell and tissue banking. - London, 2000, currens
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Publication
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Dordrecht
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Springer
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2024
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ISSN
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1389-9333
1573-6814
[online]
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DOI
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10.1007/S10561-023-10106-Z
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Volume/pages
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25
(2024)
, p. 509-520
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ISI
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001059904000001
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Pubmed ID
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37624485
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Full text (Publisher's DOI)
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Full text (open access)
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