Publication
Title
A new alkaloid from Pancratium maritimum : structure elucidation using computer-assisted structure elucidation (CASE) and evaluation of cytotoxicity and anti-SARS-CoV-2 activity
Author
Abstract
Pancratium maritimum L. (or ‘sea daffodil’) is one of the most studied plant species in the Amaryllidaceae family. Recently, due to the advancement of new probabilistic methods and spectroscopic techniques, the potential for phytochemical investigations on isomeric compounds has significantly improved. In this study, application of these techniques in combination with conventional phytochemical analysis led to the isolation and identification of a new alkaloid named 2β,10bα-dihydroxy-9-O-demethylhomolycorine from P. maritimum, together with 17 known ones. Assessment of anti-SARS-CoV-2 activity and cytotoxicity on a Vero E6 cell line for all compounds revealed four compounds with weak anti-SARS-CoV-2 potency at non-cytotoxic concentrations, namely of 9-Odemethylhomolycorine (EC50 = 44 μM), galanthamine (EC50 = 70 μM), 1-O-acetyl-norpluviine (EC50 = 80 μM) and 1-O-acetyl-10-O-methylpseudolycorine (EC50 = 47 μM). On the other hand, cytotoxicity was observed for 2β,10bα-dihydroxy-9-O-demethylhomolycorine (CC50 = 13.28 μM), haemanthamine (CC50 = 0.76 μM), 6α- and 6β-haemanthidine (CC50 = 5.43 μM), 11-hydroxyvittatine (CC50 = 10.57 μM) and pseudolycorine (CC50 = 3.41 μM).
Language
English
Source (journal)
Phytochemistry letters
Publication
2023
ISSN
1874-3900
DOI
10.1016/J.PHYTOL.2023.09.006
Volume/pages
58 (2023) , p. 1-7
ISI
001083116400001
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Anti-inflammatory iridoids and alkaloids from some widely used and some less explored medicinal plants.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 22.03.2024
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