Publication
Title
Neuroglial components of brain lesions may provide new therapeutic strategies for multiple sclerosis
Author
Abstract
Multiple sclerosis (MS) is a chronic autoimmune and demyelinating disease of the central nervous system (CNS) which leads to focal demyelinated lesions in the brain and spinal cord. Failure of remyelination contributes to chronic disability in young adults. Characterization of events occurring during the demyelination and remyelination processes and those of which subsequently limit remyelination or contribute to demyelination can provide the possibility of new therapies development for MS. Most of the currently available therapies and investigations modulate immune responses and mediators. Since most therapeutic strategies have unsatisfied outcomes, developing new therapies that enhance brain lesion repair is a priority. A close look at cellular and chemical components of MS lesions will pave the way to a better understanding of lesions pathology and will provide possible opportunities for repair strategies and targeted pharmacotherapy. This review summarizes the lesion components and features, particularly the detrimental elements, and discusses the possibility of suggesting new potential targets as therapies for demyelinating diseases like MS.
Language
English
Source (journal)
Neurological sciences. - New York, N.Y., 2000, currens
Publication
New York, N.Y. : 2023
ISSN
1590-1874 [print]
1590-3478 [online]
DOI
10.1007/S10072-023-06915-5
Volume/pages
44 (2023) , p. 3795-3807
ISI
001023389200003
Pubmed ID
37410268
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Research group
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 02.10.2023
Last edited 15.10.2024
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