Publication
Title
A review of nemorosone: Chemistry and biological properties
Author
Abstract
Nemorosone is a bicyclic polyprenylated acylphloroglucinol derivative originally isolated from Clusia spp. and it can be obtained through chemical synthesis employing different synthetic strategies. Since its discovery, it has attracted great attention both from a biological and chemical viewpoint. In the present article, we attempted to review various chemical and biological topics around nemorosone, with an emphasis on its antiproliferative activities. For this purpose, relevant data was collected from different scientific databases including Google Scholar, PubMed, Scopus and ISI Web of Knowledge. This natural compound has shown activity against several types of malignancies such as leukemia, human colorectal, pancreatic, and breast cancer because it modulates multiple molecular pathways. Nemorosone has both cytostatic and cytotoxic activity and it also seems to induce apoptosis and ferroptosis. Additionally, it has antimicrobial capabilities against Gram-positive bacteria and parasites belonging to genus Leishmania. Its promising antiproliferative pre-clinical effects deserve further attention for anticancer and anti-parasitic drug development and translation to the clinic.
Language
English
Source (journal)
Phytochemistry: an international journal of plant biochemistry. - Oxford
Publication
Oxford : Pergamon-elsevier science ltd , 2023
ISSN
0031-9422
DOI
10.1016/J.PHYTOCHEM.2023.113674
Volume/pages
210 (2023) , 14 p.
Article Reference
113674
ISI
000982167900001
Pubmed ID
37044362
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Research group
Publication type
Subject
External links
Web of Science
Record
Identifier
Creation 11.10.2023
Last edited 25.04.2024
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