Publication
Title
Proteomic assessment of C57BL/6 hippocampi after non-selective pharmacological inhibition of all nitric oxide synthase activity
Author
Abstract
Nitric oxide is the smallest gaseous signaling molecule responsible for maintaining homeostasis in a myriad of tissues and molecular pathways in neurological and cardiovascular pathologies. In recent years, there has been increasing interest in the potential interaction between arterial stiffness (AS), an independent cardiovascular risk factor, and neurodegenerative syndromes given increasingly epidemiological study reports. For this reason, we previously sought to investigate the mechanistic convergence between AS and neurodegeneration via the progressive non-selective inhibition of all nitric oxide synthase (NOS) isoforms with N(G)-nitro-L-arginine methyl ester (L-NAME) in C57BL/6 mice. Our results showed progressively increased arterial stiffness in vivo and impaired visuospatial learning and memory in L-NAME treated C57BL/6 mice. In this study, we sought to further investigate the progressive molecular signatures in hippocampal tissue via LC-MS/MS proteomic analysis
Language
English
Related publication(s)
Publication
PRIDE - PRoteomic IDEntifications Database , 2022
Volume/pages
Pubmed ID
35892672
Note
ProteomeXchange accession: PXD033646
UAntwerpen
Faculty/Department
Research group
Project info
Arterial stiffening as a common pathophysiological mechanism in cardiac and kidney failure and brain degeneration.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Source file
Record
Identifier
Creation 12.10.2023
Last edited 17.10.2023
To cite this reference